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Editorial comment - The updated Cochrane review 2014
The availability of gonadotrophin-releasing hormone agonist (GnRHa) as a trigger has been an important development in reducing the risk of ovarian hyper-stimulation syndrome. There is continued debate about whether all embryos should be routinely cryopreserved following GnRHa trigger or if there is utility under such circumstances in a fresh embryo transfer combined with appropriate luteal phase support. This manuscript discusses a potential concern regarding the methodology used in the most recent Cochrane review on this subject. The authors suggest that differing approaches to luteal phase support impacted on pregnancy rates observed in those studies included within the review and so may have biased the conclusion(s) of the review.The updated Cochrane review 2014 on GnRH agonist trigger: repeating the same errors By Shahar Kol, Peter Humaidan, Birgit Alsbjerg, Lawrence Engmann, Claudio Benadiva, Juan A. García-Velasco, Human Fatemi and Claus Yding Andersen
Editorial Comment - Genetic polymorphism and recurrent miscarriage
Despite increased efforts recurrent miscarriages still account for at least 1-2% of women in the reproductive age. One third can not be explained following elaborate investigations. Detecting further reasons is highly welcome, even if it seems hard to distinguish against the population variations. Therefore it is necessary that statistical power and clinical consequences are respected. Both articles, Haroun et al. 2014 and Andraweera et al 2014 seem to take care of this fact, therefore pointing to additional pathways. To accelerate the process of finding relevant influencing factors, genome wide studies seem to be appropriate. This needs to be accompanied by basic research for example in understanding the genetic background of meiotic processes to comprehend recurrent aneuploidies.Genetic polymorphism and recurrent miscarriage By T.C. Li Reproductive BioMedicine Online, Volume 29, Issue 6, Pages 657–658
PD Dr. Tina Buchholz
Scientific director for IFFS
About the Editor
4 October - 9 October
XXI FIGO World Congress of Gynecology and Obstetrics
17 October - 21 October
71st Annual Meeting of the ASRM
ASRM2015 is the premier reproductive medicine meeting of the year, boasting phenomenal scientific, postgraduate, and video programs. Plenary lectures by noted luminaries in the field will address state-of-the-art issues in reproductive medicine and science.
3 November - 6 November
12th World Congress of Perinatal Medicine
The city of Madrid will be the home of the 12th World Congress of Perinatal Medicine, where key opinion leaders, experts in maternal and neonatal medicine and delegates will share their knowledge and discuss the most exciting topics. The best clinical practice, research and teaching will all together join during a few days in our city to answer burning questions. Controversial topics will be discussed to better analyze our present knowledge but focus in building together the future of perinatal medicine in accordance with the scientific evolution.